Not at all, it is like any other treks around Nepal Himalaya, the only difference that you will be far away from main villages, where good lodges are not available except for few simple places to stay overnights with the limited food menu, walk involves ups and down the only tough day is a hike to Khair Lake from Khopra ridge just for a day, as long you take it slowly it will be easier.
Most of the walk offers grand views of high Annapurna, and Dhaulagiri mountain range with ever-present Machhapuchare Himal, the Fish-Tail peak. Walking into lovely green woodland lined with tall rhododendron and pine trees. The dramatic beautiful scenery of landscapes, beside mountain views where one can enjoy visiting villages at Ghandruk and Ghorepani of the impressive local culture of both Hindu and Buddhism religions.
Best in April and May during mid and late springtime, autumn or fall is another good time for treks to Khopra Ridge. Autumn in Nepal starts from September till November. April to May and September till November are the best times, where days are clear and sunny for excellent views of beautiful landscapes and high snow-capped peaks. But with cold morning and in the late afternoon till night time as well in the shades. Can get snow sometimes even in good time of the season, especially on higher areas around Khopra and Khair Lake.
On this trek to Khopra Ridge, the nearest hospitals and medical post located in Nayapul and Pokhara which is at the end of a trek. For serious situations from other medical reasons like accidents or personal medical problems. If the member cannot continue the trek, needs to be taken back to Pokhara or Kathmandu. The fastest transport is calling for helicopter service. In this emergency case where victims have to bear all the expenses to be claimed from health and medical insurance.
Besides, Pokhara in Ghandruk and at Khopra Ridge as well at Sauta and Ghorepani villages, there will be no facilities to charge your electronic items for few days only. Places, where you can charge on treks, need to pay a certain amount for charging each item.
At Ghandruk, Ghorepani of tourist standard with a list of the international quality food menu, having large rooms with attached or common bathrooms that runs hot and cold water for showers or bathe. From Dobato and at Khopra Ridge lodges are very simple having common toilets and bathrooms. Food menus are simple and shortlisted, best to enjoy local Nepalese Dal Bhat (Boiled rice, lentil soup with mild vegetable curries includes some hot pickles to add with your meals.)